The webserver iNR-Drug was developed for predicting interaction between NRs and drugs in the cellular networks. It has the following features: (i) each drug compound is formulated by a 2D fingerprint with a 256D feature vector; (ii) each NR formulated by the 500D Chouí»s PseAAC generated with the grey PSSM and dipeptide composition; (iii) the prediction engine is operated by the SVM algorithm. The anticipated overall success rate in identifying interactive NR-drug pairs and non-interactive NR-drug pairs is about 89%.
To obtain the predicted result with the anticipated success rate, the entire sequence of a query NR rather than its fragment should be used as an input. A sequence with less than 50 amino acid residues is generally deemed as a fragment. Also, if the query protein sequence is known to be not a NR, stop the prediction because the result thus obtained will not make any sense.