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The web-server iCatalytic-PseAAC is a web server that could predict methylation sites in proteins. With the assistance of FKNN, the highlight of iCatalytic-PseAAC is to employ amino acid sequence features extracted by incorporating the sequence evolution information into PseAAC via a grey system model (Grey-PSSM). The class-balanced accuracy and MCC of iCatalytic-PseAAC reached 87.52% and 55.14% for Training set, and 83.07% and 50.89% for Testing set.
To obtain the predicted result with the anticipated success rate, the entire sequence of the query protein rather than its fragment should be used as an input.